Inflammaging and Biological Ageing – How Silent Inflammation Accelerates the Ageing Process

Ältere Frau schaut aus dem Fenster

Perhaps this sounds familiar: You’re generally healthy, but still often feel tired, run-down, or just not as energetic as you used to be – even though you’re not actually that old yet. Routine blood tests come back normal. Your doctor’s verdict: “That’s just part of getting older.” But what if it’s not just normal ageing? What if a process is quietly at work in your body – slowly damaging your cells, fuelling chronic inflammation, and making your biological clock tick faster than it should? This process has a name: Inflammaging.

The term describes a state of low-grade, chronic inflammation that arises and persists without any obvious infection or injury – and over time, damages cells, accelerates biological ageing, and contributes to the onset of age-related diseases.

Here’s what you need to know about this “invisible” process – and what you can do to counter it.

What exactly is Inflammaging?

“Inflammaging” is a hybrid term combining “inflammation” and “ageing” – it refers to inflammation-driven ageing. Coined in 2000 by Italian immunologist Claudio Franceschi, the term describes a subtle yet persistent inflammatory state that becomes more common with age, even in the absence of acute illness.

Today, research clearly shows that these silent inflammations accelerate biological ageing and contribute to chronic diseases including cardiovascular disease, Alzheimer’s, type 2 diabetes, osteoporosis, and cancer.

Scientifically speaking, it involves a chronic overactivation of the immune system, leading to:

  • Increased levels of inflammatory messengers (e.g. IL-6, TNF-α, CRP)
  • Elevated oxidative stress
  • Impaired cellular regeneration

Unlike classic inflammation – a natural, time-limited healing response to infection or injury – Inflammaging creeps in without clear symptoms: no fever, no swelling, no redness, no pain. Many people simply feel chronically exhausted, prone to infections, or generally less vital. But underneath, the body is caught in a long-term, smouldering state of inflammation that gradually weakens tissues and disrupts regeneration.

How does Inflammaging develop?

Ageing is a complex process, but Inflammaging often plays a central role. Several biological mechanisms, especially in combination, are known to promote chronic low-grade inflammation:

1. Impaired Autophagy – When the Body’s Cellular Cleanup Slows Down

Cells are constantly at work: dividing, renewing, performing vital tasks. This generates waste and damaged components – so-called cellular debris. Autophagy, the body’s internal cleaning process, breaks down and recycles this debris.

If autophagy becomes less efficient, the risk of chronic inflammation – and thus Inflammaging – rises.

The term “autophagy” means “self-digestion” and describes the natural process by which cells identify, break down, and recycle waste materials, defective components, and aggregated proteins.

As we grow older, multiple risk factors tend to accumulate, which can significantly impair the body’s ability to carry out autophagy. As a result, cellular waste builds up, damaged components remain inside the cells, reactive oxygen species (ROS) – aggressive oxygen compounds that can damage cell membranes and DNA – increase, and the risk of low-grade (silent) inflammation continues to rise.

2. Oxidative Stress

Oxidative stress occurs when free radicals overwhelm the body’s antioxidant defences. Free radicals are unstable molecules that damage cellular structures such as membranes, proteins, and even DNA as they seek to stabilise themselves by stealing electrons from other molecules.

While free radicals naturally arise in the body through normal metabolic processes – for example, in the mitochondria during energy production or as part of the immune response – external influences such as UV radiation, pollution, smoking, alcohol, and chronic inflammation can dramatically increase their production.

When antioxidant levels are too low to neutralise them the balance tips, oxidative stress ensues. This activates inflammatory signalling pathways and is now recognised as a major contributor to Inflammaging.

3. Mitochondrial Dysfunction

Mitochondria – often referred to as the “powerhouses of the cell” – are found in nearly all human cells. Their main task is to convert nutrients such as glucose and fatty acids into energy that the body can use (ATP).

As we age, mitochondrial efficiency often declines. This means they produce less energy while simultaneously generating more reactive oxygen species (ROS) – aggressive molecules that can trigger inflammatory processes in the body.

Impaired mitochondrial function is now recognised as both a cause and a consequence of Inflammaging – and is believed to significantly contribute to the persistent fatigue and lack of energy that many people experience as they age.

4. Senescent Cells

A decline in autophagy, oxidative stress, mitochondrial dysfunction, and other harmful influences can cause cells to become senescent. These are aged or damaged cells that no longer divide but, unlike healthy cells, are not properly cleared from the body. Although they’ve lost their original function, they remain metabolically active – and that’s a problem.

Senescent cells release a cocktail of pro-inflammatory signalling molecules, drawing in immune cells even though there is no actual threat to respond to. The result is a chronic activation of the immune system, which begins to fight ‘nothing’ and thereby sustains a low-grade inflammatory state – with damaging long-term effects on surrounding tissues and organs.

As the number of these senescent cells grows, surrounding tissues become increasingly affected – setting off a chain reaction of smouldering inflammation that can spread progressively throughout the body.

5. Gut Health and the Microbiome

In a healthy state, the intestinal lining ensures that only properly broken-down food components – such as amino acids, fatty acids, simple sugars, and micronutrients like vitamins and minerals – pass in a controlled manner into the bloodstream, where they serve as building blocks, sources of energy, and functional cofactors for the body.

However, certain influences – including chronic stress, antibiotics, a diet high in sugar, alcohol, ultra-processed foods, or low in fibre – can gradually alter the composition of the gut microbiome, leading to what is known as dysbiosis. This means that the microbial balance shifts in favour of potentially harmful bacteria. Over time, this can weaken the protective barrier function of the intestinal lining and result in increased permeability – the so-called “leaky gut syndrome.”

As a result, incompletely digested food particles, bacterial fragments, and toxins can pass unfiltered into the bloodstream. Because these molecules do not belong there, the immune system identifies them as potential threats and mounts a defensive response. This immune activation contributes to systemic, body-wide inflammation and can further accelerate the process of Inflammaging.

All these biological processes are interconnected and can reinforce each other. Mitochondrial damage, impaired autophagy, oxidative stress, cellular senescence, as well as microbiome imbalance and leaky gut together lay the foundation for low-grade inflammation that gradually affects the entire body.

The longer this silent inflammation persists, the more it drives our biological ageing and impacts overall health.

The good news? Many of these mechanisms can be actively influenced and brought back into balance.

Why is Inflammaging dangerous?

Even slightly elevated inflammatory markers can affect not just individual organs but the entire body. Chronic low-grade inflammation can:

  • Damage cells and impair their ability to divide
  • Shorten telomeres – the protective caps on our DNA – reducing cellular lifespan
  • Inhibit repair and regeneration processes
  • Harm blood vessels and promote atherosclerosis
  • Increase insulin resistance
  • Weaken nerve cells and accelerate neurodegenerative processes

Subtle symptoms may be the first warning signs of Inflammaging: persistent fatigue, slowed skin regeneration, digestive issues, mental exhaustion, poor sleep – or frequent headaches and migraines. Inflammatory activity in the brain may also contribute to psychological conditions such as depression, chronic fatigue, and sleep disorders.

Today, extensive research confirms that Inflammaging plays a central role in the development of many age-related diseases – including cardiovascular disease, type 2 diabetes, Alzheimer’s and other dementias, osteoporosis, autoimmune conditions, and cancer.

But it goes even further: Inflammaging doesn’t just fuel the development of individual diseases – it also accelerates the ageing process itself. Researchers now consider it a core biological mechanism of ageing, rather than merely a side effect.

Inflammaging is therefore not a normal or inevitable part of growing older – but a serious and modifiable risk factor for chronic illness and premature ageing. The problem? These silent inflammatory processes can simmer unnoticed in the background for decades.

Women, Hormones, and Silent Inflammation

During the hormonal transition that begins for many women in the years leading up to menopause (perimenopause), oestrogen levels often decline earlier and more sharply than progesterone levels – creating a relative hormonal imbalance.

Oestrogen has anti-inflammatory properties, among other functions. Its comparatively steeper decline can intensify inflammatory processes, particularly in the skin, joints, and brain. This helps explain why many women in this phase of life report symptoms such as fatigue, sleep disturbances, mood swings, or diffuse joint pain

Can Inflammaging be measured?

Although silent inflammation often progresses without noticeable symptoms, certain laboratory markers can provide valuable clues:

  • CRP (C-reactive protein) – A general marker of inflammation. Even mildly elevated levels (e.g. 1–3 mg/L) may indicate chronic inflammatory activity in the absence of acute infection.
  • IL-6 (Interleukin 6) – A signalling molecule that plays a central role in initiating and sustaining Inflammaging.
  • TNF-α (Tumour Necrosis Factor alpha) – A pro-inflammatory cytokine commonly elevated in chronic inflammatory conditions.
  • Homocysteine – An amino acid associated with oxidative stress, vascular damage, and systemic inflammation.
  • Fibrinogen – A clotting protein that also increases in response to inflammatory stimuli.

A single marker such as CRP is usually not sufficient to reliably detect silent inflammation. More informative is a combination of several markers (e.g. CRP, IL-6, TNF-α), evaluated alongside individual symptoms and risk factors. This approach can help identify elevated risk levels even before clinical symptoms emerge.

Important: In preventative medicine, even CRP levels above 1 mg/L – though still within the “normal” range – are considered early warning signs of increased inflammatory and disease risk.

Because these markers can fluctuate in response to short-term influences such as diet, exercise, environmental exposure, or alcohol intake, a follow-up test is often recommended.

What can you do about Inflammaging?

It was once widely believed that chronic diseases were primarily genetic – something you were born with and couldn’t change. But growing research shows that while genes do play a role, lifestyle factors are far more decisive. In other words: we have a significant influence on our long-term health – especially as we age.

Through the way you eat, live, and care for yourself, you can actively support your body and stay healthy and vibrant well into older age. Below, we’ll walk you through the most important levers you can focus on:

Diet: Eating to Calm Inflammation

A whole-food, plant-rich diet forms the cornerstone of any Anti-Inflammaging strategy. Focus on fresh vegetables, herbs, fruits, seeds, nuts, whole grains, healthy fats (like olive oil), and plenty of fibre. Drinking enough still, high-quality water is also essential.

Meat1Chen J, Campbell TC, Li J, Peto R (1990) China-Cornell-Oxford Project. Oxford University Press. → Link 1 → Link 2
The central thesis of the so-called “China Study” is based on a large-scale investigation conducted in the 1980s, in which over 6,500 individuals from 65 rural regions of China were assessed in terms of their diet and health status. The analysis revealed clear correlations between a high intake of animal protein – particularly from meat and dairy products – and an increased risk of chronic diseases such as cardiovascular disease, diabetes, and certain types of cancer. In contrast, the study highlights the health benefits of a whole food, plant-based diet (WFPB).
/2EPIC-Studie (European Prospective Investigation into Cancer and Nutrition) → Link
The EPIC study is one of the largest long-term European studies examining the relationship between diet and chronic disease. Since the 1990s, more than 500,000 people across ten countries have been followed. Findings show that the consumption of processed red meat is associated with a higher risk of colorectal cancer and cardiovascular disease, while fish tends to be rated as neutral or slightly protective. A plant-forward diet is linked to lower mortality – though a complete avoidance of animal products does not appear to be strictly necessary.
/3Adventist Health Study (AHS-2) → Link
The Adventist Health Study‑2, conducted by Loma Linda University, investigated around 96,000 members of the Seventh-day Adventist Church, many of whom follow a vegetarian lifestyle. The analysis found that vegetarian diets were associated with lower overall mortality and reduced rates of chronic disease. Overall, the data suggested a dose-response effect: the less animal protein consumed, the more favourable the health outcomes.
, refined sugar, white flour products, ultra-processed foods, and alcohol should be limited or avoided altogether.

Studies such as the PREDIMED trial4Estruch, R. et al. (2018). Primary Prevention of Cardiovascular Disease with a Mediterranean Diet Supplemented with Extra-Virgin Olive Oil or Nuts. N Engl J Med, 378(25):e34. DOI: 10.1056/NEJMoa1800389 → Link
The PREDIMED study was a randomised controlled trial conducted in Spain with 7,447 older adults at high cardiovascular risk. It compared three dietary patterns: (1) Mediterranean diet + extra virgin olive oil; (2) Mediterranean diet + nuts; and (3) a low-fat diet (control group). After a median follow-up of 4.8 years, the study was stopped early due to its clear benefits: cardiovascular events (e.g. heart attacks, strokes, cardiovascular deaths) were reduced by about 30% in both Mediterranean diet groups.
have shown that a Mediterranean-style diet rich in healthy fats can significantly reduce inflammatory markers like CRP, IL-6, and TNF-α – while also lowering the risk of cardiovascular events.

Intermittent Fasting: Cellular Clean-Up Through Targeted Meal Breaks

Intermittent fasting can also help reduce silent inflammation. This involves regularly refraining from food intake for a specific time window each day – for example, fasting for 16 hours and eating within an 8-hour window (known as the 16:8 method). During fasting periods, the body’s internal clean-up mechanism – autophagy – is more strongly activated. Damaged cellular components and waste products are broken down more efficiently, which may help reduce pro-inflammatory processes in the body. Studies suggest that regular intermittent fasting not only supports metabolic health but may also directly impact key ageing mechanisms such as Inflammaging5de Cabo, R. et al. (2019). Effects of Intermittent Fasting on Health, Aging, and Disease. N Engl J Med, 381(26):2541-2551. DOI: 10.1056/NEJMra1905136 → Link
Key findings of this publication: Intermittent fasting promotes autophagy, reduces oxidative stress, lowers inflammation, and positively influences core biological ageing mechanisms, including Inflammaging.
.

Movement: Consistent, Not Excessive

Exercise acts as a natural anti-inflammatory. Physical activity helps reduce pro-inflammatory messengers, stimulates muscle tissue, and has a positive influence on the gut microbiome.

The ideal routine includes:

  • At least 140 minutes of moderate activity per week (e.g. brisk walking, swimming, cycling)
  • Two to three sessions of light to moderate strength training
  • Regular movement throughout the day (e.g. taking the stairs instead of the lift)

However, too much exercise – especially high-intensity endurance training – can have the opposite effect. It increases the release of stress hormones and inflammatory messengers, which may actually worsen Inflammaging rather than prevent it.

Reduce Excess Weight

Maintaining a healthy body weight is a key factor in reducing silent inflammation. Fat cells – especially visceral fat around the abdomen – are metabolically active and release pro-inflammatory signalling molecules. This keeps the immune system in a state of chronic activation.

Studies show that losing excess weight, particularly the reduction of abdominal fat, can significantly lower inflammatory markers such as CRP and contribute to improved overall health6Saijo, Y. et al. (2004). Relationship between C-reactive protein and visceral adipose tissue in healthy Japanese subjects. Diabetes Obes Metab, 6(4):249-58. DOI: 10.1111/j.1462-8902.2003.0342.x → Link/7Campbell, P.T. st al. (2009). A yearlong exercise intervention decreases CRP among obese postmenopausal women. Med Sci Sports Exerc, 41(8):1533-9. DOI: 10.1249/MSS.0b013e31819c7feb → Link.

Mind–Body Connection: Regulate Stress, Strengthen Emotional Wellbeing

Chronic stress is one of the most underestimated drivers of low-grade inflammation. It activates the sympathetic nervous system and the hypothalamic–pituitary–adrenal (HPA) axis, leading to increased secretion of the stress hormone cortisol.

While cortisol is anti-inflammatory in the short term, chronically elevated levels disrupt immune balance, raise levels of pro-inflammatory messengers such as IL-6 and TNF-α, and keep the body in a prolonged state of alarm. Chronic stress also affects the gut microbiome, further fuelling inflammation.

Targeted stress regulation can help interrupt this cycle. Recommended strategies include:

  • Regular sleep (7–9 hours), as restorative sleep supports immune balance
  • Mindfulness practices such as meditation, conscious breathing techniques, yoga, or time in nature, which are proven to calm the nervous system and lower inflammation
  • Reducing overstimulation, e.g. by limiting screen time, taking digital breaks, and consciously slowing down your daily pace

Even small relaxation rituals, when practised regularly, can help reduce inflammation and strengthen physical resilience.

Research in psychoneuroimmunology (PNI) and salutogenesis increasingly suggests that positive emotions, social connection, a sense of purpose, joy, and fulfilling relationships can calm the nervous system, reduce cortisol levels, activate the parasympathetic branch – and thereby support the body’s anti-inflammatory balance. In other words: do more of what brings you joy – whether it’s music, movement, creativity, or spending time with loved ones. Positive emotions and social bonds help regulate stress and contribute meaningfully to healthy ageing.

Nourishing your soul is cellular care, too.

Botanical Compounds & Micronutrients: Naturally Effective Against Silent Inflammation

Certain bioactive plant compounds and micronutrients have been shown in studies to help regulate inflammation — without the side effects associated with many conventional medications. You’ll learn more about them in the next section.

Supplements and Natural Compounds to Help Protect Against Inflammaging

In addition to a healthy lifestyle, certain natural substances can actively support the regulation of inflammation-driven ageing — and may help slow it down. Studies show that many of these compounds influence inflammatory and ageing-related processes on multiple levels at once.

Examples of well-researched, bioactive natural substances include:

Astragalus membranaceus

Astragalus membranaceus is one of the most important medicinal plants in Traditional Chinese Medicine (TCM). Studies have shown that it can increase telomerase activity8Liu, P. et al. (2017). Anti-Aging Implications of Astragalus Membranaceus (Huangqi): A Well-Known Chinese Tonic. Aging and Disease, 1;8(6):868–886. DOI: 10.14336/AD.2017.0816 → Link – the body’s natural “cellular protection mechanism”, which declines with age. It also has antioxidant and inflammation-modulating properties9Adesso, S.et al. (2018). Astragalus membranaceus Extract Attenuates Inflammation and Oxidative Stress in Intestinal Epithelial Cells via NF-κB Activation and Nrf2 Response. International Journal of Molecular Sciences, 19(3), 800. DOI: 10.3390/ijms19030800 → Link.

Spermidine

Spermidine is a naturally occurring compound found in every living cell. It promotes autophagy – the body’s cellular cleaning process – and helps protect against cell damage. As we age, the body’s own production of spermidine declines. Studies have shown that supplemental spermidine can slow down the ageing process and support immune function10Madeo, F.et al. (2018). Spermidine in health and disease. Science, 359(6374), eaan2788. DOI: 10.1126/science.aan2788 → Link/11Eisenberg, T. et al. (2009). Induction of autophagy by spermidine promotes longevity. Nature Cell Biology, 11(11), 1305–1314. DOI: 10.1038/ncb1975 → Link.

Chaga Mushroom

Chaga is a medicinal mushroom rich in melanin, polyphenols, and beta-glucans. It has strong antioxidant properties, supports the immune system, and inhibits inflammatory pathways such as NF-κB12Hu, B. et al. (2021). Effect of Inonotus obliquus polysaccharide on composition of the intestinal flora in mice with acute endometritis. PLOS ONE, 16(11): e0259570. DOI: 10.1371/journal.pone.0259570 → Link.

Resveratrol

A polyphenol naturally found in red grapes. Resveratrol activates sirtuins – enzymes often referred to as “longevity genes”. It also has anti-inflammatory and vascular-protective properties13Baur, J. A., & Sinclair, D. A. (2006). Therapeutic potential of resveratrol: the in vivo evidence. Nature Reviews Drug Discovery, 5(6), 493–506. DOI: 10.1038/nrd2060 → Link/14Ørstrup, M. J.et al. (2014). Resveratrol increases bone mineral density and bone alkaline phosphatase in obese men: a randomized placebo-controlled trial. The Journal of Clinical Endocrinology & Metabolism, 99(10), 3450–3458. DOI: 10.1210/jc.2014-2799 → Link
In this placebo-controlled study of 66 overweight men (150 mg/day), the patented Veri-te™ Resveratrol significantly increased bone mineral density and levels of anti-inflammatory enzymes, highlighting its health-promoting effects. Veri-te™ is a high-purity, sustainably produced trans-resveratrol made in Europe through a patented fermentation process. Unlike plant-based extracts that may be contaminated with heavy metals or environmental toxins, Veri-te™ offers consistent purity, excellent bioavailability, and is backed by clinical studies demonstrating its benefits for heart health, inflammation control, and cellular protection.
.

Quercetin

A flavonoid found in foods such as onions, apples, and capers. It inhibits enzymes like COX-2 and lipoxygenases, which are involved in inflammatory responses, and works synergistically with other antioxidants15Boots, A. W.et al. (2008). Health effects of quercetin: from antioxidant to nutraceutical. European Journal of Pharmacology, 585(2–3), 325–337. DOI: 10.1016/j.ejphar.2008.03.008 → Link.

Curcumin

The yellow compound from turmeric is one of the best-known natural anti-inflammatories. It blocks key inflammatory pathways and has been shown to lower CRP levels16Aggarwal, B. B. et al. (2007). Curcumin: The Indian solid gold. In: The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease (Advances in Experimental Medicine and Biology), Vol. 595, S. 1–75). Springer. DOI: 10.1007/978-0-387-46401-5_1 → Link/17Jurenka, J. S. (2009). Anti‑inflammatory properties of curcumin, a major constituent of Curcuma longa: A review of preclinical and clinical research. Alternative Medicine Review, 14(2), 141–153 → Link/18Amalraj, A. et al. (2019). The Effects of Bioavailable Curcumin (Cureit™) on Delayed Onset Muscle Soreness Induced by Eccentric Continuous Exercise: A Randomized, Placebo-Controlled, Double-Blind Clinical Study. Journal of Medicinal Food, 22(2), 167–175. DOI: 10.1089/jmf.2019.4533 → Link
In this human double-blind study, Cureit™ significantly reduced delayed onset muscle soreness (DOMS) and improved markers of inflammation and oxidation after eccentric exercise, compared to placebo. Cureit™ is a patented, 100% natural turmeric extract that preserves the full spectrum of bioactive compounds in turmeric root in their natural matrix. Studies show that Cureit™ offers approximately ten times higher bioavailability than standard turmeric extracts – a key advantage, as curcumin is otherwise poorly absorbed by the body.
.

Rosehip

Rich in vitamin C, flavonoids, and galactolipids. Rosehip has antioxidant properties and supports collagen formation – important for firm skin as well as healthy joints and bones, which often decline with age. Its anti-inflammatory action also helps reduce joint discomfort19Winther, K. et al. (2005). A powder made from seeds and shells of a rose-hip subspecies (Rosa canina) reduces symptoms of knee and hip osteoarthritis: a randomized, double-blind, placebo-controlled clinical trial. Scand J Rheumatol, 34(4):302-8. DOI: 10.1080/03009740510018624 → Link
In this randomised, double-blind, placebo-controlled trial of 94 participants with hip or knee osteoarthritis, daily intake of 5 g rosehip powder over three months led to a significant reduction in pain (measured by WOMAC pain score) after just three weeks, along with reduced use of pain medication.
.

Hyaluronic Acid

Known for its role in skincare but also effective internally: High-molecular-weight hyaluronic acid (≥ 800 kDa) helps regulate inflammation and supports healthy joint structure. Studies show that larger molecules can reduce specific inflammatory messengers in the body, contributing to tissue regeneration and cellular protection20Tavianatou. A.G. et al. (2019). Hyaluronan: molecular size-dependent signaling and biological functions in inflammation and cancer. FEBS J. 286(15):2883-2908. DOI: 10.1111/febs.14777 → Link.

Nicotinamide (Vitamin B3)

Nicotinamide is a precursor of NAD⁺ – a molecule essential for energy production in every cell21Revollo, J.R. et al. (2007). The regulation of nicotinamide adenine dinucleotide biosynthesis by Nampt/PBEF/visfatin in mammals. Curr Opin Gastroenterol, 23(2):164-70. DOI: 10.1097/MOG.0b013e32801b3c8f → Link. It supports healthy mitochondrial function and promotes cell regeneration. Studies also indicate that nicotinamide may reduce inflammation and protect cells from oxidative stress and DNA damage22Surjana, D. et al. (2013). Nicotinamide enhances repair of ultraviolet radiation-induced DNA damage in human keratinocytes and ex vivo skin. Carcinogenesis, 34(5):1144-9. DOI: 10.1093/carcin/bgt017 → Link.

All of the above-mentioned bioactive plant compounds and micronutrients are included in Synergo juvenis in carefully balanced, evidence-based, and bioactive dosages – offering a practical nutrient synergy for healthy ageing. This allows you to actively support your body’s natural defences against Inflammaging and integrate them effortlessly into your daily routine.

  • Synergo juvenis healthy ageing and longevity
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    Synergo juvenis

    Nutrient complex: Healthy ageing formula

Conclusion: Inflammaging is not your destiny – much lies in your own hands

We are all affected by Inflammaging to some extent – but we’re not powerless. Research is clear: those who take early action and make conscious lifestyle choices can reduce chronic inflammation, strengthen cellular health, and stay healthier, more energetic, and resilient for longer.

The key lies in a holistic approach combining healthy nutrition, regular movement, mindfulness, stress regulation, and the targeted intake of bioactive plant compounds and micronutrients – holistic, natural, and sustainable.

It’s the small, everyday decisions that make a big difference over time: Do you reach for a bag of sweets or an apple? Do you stay on the sofa or go for a walk in the park or forest? Do you let a stressful situation get to you – or remain calm and optimistic? The choice is yours!

And don’t worry – it’s not about perfection or rigid rules. Quite the opposite: a healthy lifestyle should bring joy. Enjoy life consciously and stay vibrant for longer – it’s a goal you can absolutely achieve when you understand the connections and make daily choices that support your wellbeing.

 

  • 1
    Chen J, Campbell TC, Li J, Peto R (1990) China-Cornell-Oxford Project. Oxford University Press. → Link 1 → Link 2
    The central thesis of the so-called “China Study” is based on a large-scale investigation conducted in the 1980s, in which over 6,500 individuals from 65 rural regions of China were assessed in terms of their diet and health status. The analysis revealed clear correlations between a high intake of animal protein – particularly from meat and dairy products – and an increased risk of chronic diseases such as cardiovascular disease, diabetes, and certain types of cancer. In contrast, the study highlights the health benefits of a whole food, plant-based diet (WFPB).
  • 2
    EPIC-Studie (European Prospective Investigation into Cancer and Nutrition) → Link
    The EPIC study is one of the largest long-term European studies examining the relationship between diet and chronic disease. Since the 1990s, more than 500,000 people across ten countries have been followed. Findings show that the consumption of processed red meat is associated with a higher risk of colorectal cancer and cardiovascular disease, while fish tends to be rated as neutral or slightly protective. A plant-forward diet is linked to lower mortality – though a complete avoidance of animal products does not appear to be strictly necessary.
  • 3
    Adventist Health Study (AHS-2) → Link
    The Adventist Health Study‑2, conducted by Loma Linda University, investigated around 96,000 members of the Seventh-day Adventist Church, many of whom follow a vegetarian lifestyle. The analysis found that vegetarian diets were associated with lower overall mortality and reduced rates of chronic disease. Overall, the data suggested a dose-response effect: the less animal protein consumed, the more favourable the health outcomes.
  • 4
    Estruch, R. et al. (2018). Primary Prevention of Cardiovascular Disease with a Mediterranean Diet Supplemented with Extra-Virgin Olive Oil or Nuts. N Engl J Med, 378(25):e34. DOI: 10.1056/NEJMoa1800389 → Link
    The PREDIMED study was a randomised controlled trial conducted in Spain with 7,447 older adults at high cardiovascular risk. It compared three dietary patterns: (1) Mediterranean diet + extra virgin olive oil; (2) Mediterranean diet + nuts; and (3) a low-fat diet (control group). After a median follow-up of 4.8 years, the study was stopped early due to its clear benefits: cardiovascular events (e.g. heart attacks, strokes, cardiovascular deaths) were reduced by about 30% in both Mediterranean diet groups.
  • 5
    de Cabo, R. et al. (2019). Effects of Intermittent Fasting on Health, Aging, and Disease. N Engl J Med, 381(26):2541-2551. DOI: 10.1056/NEJMra1905136 → Link
    Key findings of this publication: Intermittent fasting promotes autophagy, reduces oxidative stress, lowers inflammation, and positively influences core biological ageing mechanisms, including Inflammaging.
  • 6
    Saijo, Y. et al. (2004). Relationship between C-reactive protein and visceral adipose tissue in healthy Japanese subjects. Diabetes Obes Metab, 6(4):249-58. DOI: 10.1111/j.1462-8902.2003.0342.x → Link
  • 7
    Campbell, P.T. st al. (2009). A yearlong exercise intervention decreases CRP among obese postmenopausal women. Med Sci Sports Exerc, 41(8):1533-9. DOI: 10.1249/MSS.0b013e31819c7feb → Link
  • 8
    Liu, P. et al. (2017). Anti-Aging Implications of Astragalus Membranaceus (Huangqi): A Well-Known Chinese Tonic. Aging and Disease, 1;8(6):868–886. DOI: 10.14336/AD.2017.0816 → Link
  • 9
    Adesso, S.et al. (2018). Astragalus membranaceus Extract Attenuates Inflammation and Oxidative Stress in Intestinal Epithelial Cells via NF-κB Activation and Nrf2 Response. International Journal of Molecular Sciences, 19(3), 800. DOI: 10.3390/ijms19030800 → Link
  • 10
    Madeo, F.et al. (2018). Spermidine in health and disease. Science, 359(6374), eaan2788. DOI: 10.1126/science.aan2788 → Link
  • 11
    Eisenberg, T. et al. (2009). Induction of autophagy by spermidine promotes longevity. Nature Cell Biology, 11(11), 1305–1314. DOI: 10.1038/ncb1975 → Link
  • 12
    Hu, B. et al. (2021). Effect of Inonotus obliquus polysaccharide on composition of the intestinal flora in mice with acute endometritis. PLOS ONE, 16(11): e0259570. DOI: 10.1371/journal.pone.0259570 → Link
  • 13
    Baur, J. A., & Sinclair, D. A. (2006). Therapeutic potential of resveratrol: the in vivo evidence. Nature Reviews Drug Discovery, 5(6), 493–506. DOI: 10.1038/nrd2060 → Link
  • 14
    Ørstrup, M. J.et al. (2014). Resveratrol increases bone mineral density and bone alkaline phosphatase in obese men: a randomized placebo-controlled trial. The Journal of Clinical Endocrinology & Metabolism, 99(10), 3450–3458. DOI: 10.1210/jc.2014-2799 → Link
    In this placebo-controlled study of 66 overweight men (150 mg/day), the patented Veri-te™ Resveratrol significantly increased bone mineral density and levels of anti-inflammatory enzymes, highlighting its health-promoting effects. Veri-te™ is a high-purity, sustainably produced trans-resveratrol made in Europe through a patented fermentation process. Unlike plant-based extracts that may be contaminated with heavy metals or environmental toxins, Veri-te™ offers consistent purity, excellent bioavailability, and is backed by clinical studies demonstrating its benefits for heart health, inflammation control, and cellular protection.
  • 15
    Boots, A. W.et al. (2008). Health effects of quercetin: from antioxidant to nutraceutical. European Journal of Pharmacology, 585(2–3), 325–337. DOI: 10.1016/j.ejphar.2008.03.008 → Link
  • 16
    Aggarwal, B. B. et al. (2007). Curcumin: The Indian solid gold. In: The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease (Advances in Experimental Medicine and Biology), Vol. 595, S. 1–75). Springer. DOI: 10.1007/978-0-387-46401-5_1 → Link
  • 17
    Jurenka, J. S. (2009). Anti‑inflammatory properties of curcumin, a major constituent of Curcuma longa: A review of preclinical and clinical research. Alternative Medicine Review, 14(2), 141–153 → Link
  • 18
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    In this human double-blind study, Cureit™ significantly reduced delayed onset muscle soreness (DOMS) and improved markers of inflammation and oxidation after eccentric exercise, compared to placebo. Cureit™ is a patented, 100% natural turmeric extract that preserves the full spectrum of bioactive compounds in turmeric root in their natural matrix. Studies show that Cureit™ offers approximately ten times higher bioavailability than standard turmeric extracts – a key advantage, as curcumin is otherwise poorly absorbed by the body.
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    In this randomised, double-blind, placebo-controlled trial of 94 participants with hip or knee osteoarthritis, daily intake of 5 g rosehip powder over three months led to a significant reduction in pain (measured by WOMAC pain score) after just three weeks, along with reduced use of pain medication.
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Health talk
How to boost cognitive performance – and keep your brain naturally healthy

Where:

Synergo Studio, Uhingen (near Stuttgart, Germany)

When:

November 13, 7:30 pm

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Rundum-Versorgung
Mikronährstoffe in optimaler Kombination aktivieren deinen Stoffwechsel – die Grundlage aller lebenswichtigen Vorgänge im Körper. Für Wohlbefinden und gesundes, jugendliches Aussehen.
Vitamine, Mineralien, Spurenelemente und mehr bringen deine Immunabwehr auf Hochtouren, wirken entzündungshemmend und schützen vor Krankheitserregern.
Antioxidantien wie Zink, Selen, Vitamin C, E, B2 und viele Pflanzenstoffe wirken entzündungshemmend und schützen deine Zellen vor oxidativem Stress, der Auslöser für viele Krankheiten und das Altern ist.

Basische Mineralstoffe und Spurenelemente unterstützen die Säure-Basen-Balance. Zudem wirken basenbildende pflanzenbasierte Zutaten in Rohkostqualität einer Übersäuerung entgegen, die Ursache vieler Zivilisationskrankheiten sein kann.

Präbiotika, Polyphenole, Aminosäuren, Bitterstoffe und mehr unterstützen deinen Magen-Darm-Trakt und fördern eine gesunde Darmflora – der Schlüssel zu körperlicher und geistiger Gesundheit.

Natürliche Vitalstoffe stärken deine körpereigenen Entgiftungsorgane. Zusätzlich unterstützt Chlorella die Ausleitung von Giften und Schwermetallen. Silizium aus Bambus fördert die Aluminium-Ausleitung.

Pflanzliche Proteine, Omega-3-Fettsäuren, Vitamine, Mineralstoffe, Spurenelemente und Antioxidantien unterstützen den Energiestoffwechsel, helfen bei der Regeneration und reduzieren Muskelkater.